David Borchelt, PhD

Neuroscience Faculty, Staff and StudentsDavid Borchelt, PhD
Professor of Neuroscience
Director, Santa Fe Health Alzheimer’s Disease Research Center;
Investigator, McKnight Brain Institute & CTRND at the University of Florida College of Medicine

Contact Dr. Borchelt:
Office: BMS J491
Phone: 352-273-9664
email: borchelt@mbi.ufl.edu

PhD, Microbiology/Virology, Univ. of Kentucky, 1986
MS, Microbiology, Univ. of Kentucky, 1984
BS, Biology, Univ. of Kentucky, 1979
Research Focus and Aims

Over the past several years there has been tremendous progress in identifying the gene products that mediate a number of neurodegenerative disorders, including familial Alzheimer’s disease, familial amyotrophic lateral sclerosis, and Huntington’s disease. These disorders are all progressive, fatal disorders that result from the dysfunction and death of specific populations of nerve cells. In all of these disorders, a change in the amino acid sequence of specific proteins initiates a cascade of events that lead to disease. A common feature of these disorders is the accumulation of misfolded proteins or peptides in regions of the CNS affected by each disease. My laboratory is committed to investigations designed to elucidate the molecular processes by which specific mutant proteins cause disease. This work involves the use of transgenic mouse models, knockout mice, and cell culture systems to examine the effect of mutations on the function and biology of the mutated proteins. Collectively, these approaches provide insight into the molecular mechanisms of disease and have the potential to identify new therapeutic strategies for these disorders.

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